(E)-3-(7-Chloro-benzofuran-4-yl)-acrylonitrile → 3-(2,3-Dihydro-benzofuran-4-yl)-propylamine hydrochloride

HRID 1602382Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1602382
[Cl:1][C:2]1[C:10]2[O:9][CH:8]=[CH:7][C:6]=2[C:5](/[CH:11]=[CH:12]/[C:13]#[N:14])=[CH:4][CH:3]=1>C(O)(=O)C.[Pd]>[ClH:1].[O:9]1[C:10]2[CH:2]=[CH:3][CH:4]=[C:5]([CH2:11][CH2:12][CH2:13][NH2:14])[C:6]=2[CH2:7][CH2:8]1

Komponenten

4

Edukt 1

HCID 19611650(E)-3-(7-Chloro-benzofuran-4-yl)-acrylonitrile2×

Produkt 1

HCID 196116703-(2,3-Dihydro-benzofuran-4-yl)-propylamine hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

A solution of the (E)-3-(7-chloro-benzofuran-4-yl)-acrylonitrile (intermediate 3) (1.0 g) in acetic acid (30 ml) containing 10% palladium on charcoal (50 mg; 50% wet paste) and 5% platinium on charcoal (50 mg) was hydrogenated at 100 psi and 50° for 3 days. The solution was filtered through hyflo and evaporated to dryness and the residue recrystallised from isopropanol to give the title compound as white plates (583 mg).

Aufarbeitung

  1. filtrationThe solution was filtered through hyflo
  2. customevaporated to dryness
  3. customthe residue recrystallised from isopropanol

Quellen und Nachweise

ORD-Eintrag
ord-6f0510d0d41143988681b54c9514f5c0
Quelldatensatz
uspto-grants-1999_11
Patentnummer
US05981572

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