Water → Timolol Maleate

HRID 1603402

Reaktionsgleichung

Reaktionsgleichung von HRID 1603402
[CH3:1][CH2:2][CH:3]([C:5]([OH:7])=[O:6])C.[CH3:8][C:9]([NH:12][CH2:13][C@H:14]([OH:28])[CH2:15][O:16][C:17]1[C:18]([N:22]2[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)=[N:19][S:20][N:21]=1)([CH3:11])[CH3:10].[OH2:29]>C([O-])(=O)C.[Zn+2].C([O-])(=O)C>[CH3:11][C:9]([NH:12][CH2:13][C@H:14]([OH:28])[CH2:15][O:16][C:17]1[C:18]([N:22]2[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)=[N:19][S:20][N:21]=1)([CH3:8])[CH3:10].[CH:3](/[C:5]([OH:7])=[O:6])=[CH:2]/[C:1]([OH:16])=[O:29]

Komponenten

5

Edukt 3

HCID 962Water2×HCID 83142-Methylbutanoic AcidHCID 33624Timolol

Produkt 1

HCID 5281056Timolol Maleate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 11192Zinc AcetateKatalysator

Versuchsvorschrift

15 grams of Carbopol 974P is dispersed in 40 grams of heavy mineral oil USP and is added to 841.5 grams of water containing 2.5 grams of timolol meleate with vigorous stirring. 100 grams of water containing 1.0 gram of zinc acetate is added in a controlled fashion with homogenization to get a particle size distribution size below 5 micron.

Aufarbeitung

  1. customto get a particle size distribution size below 5 micron

Quellen und Nachweise

ORD-Eintrag
ord-9cca235f36404870a5655411ed51d3e0
Quelldatensatz
uspto-grants-1999_11
Patentnummer
US05989535

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