Acetic Acid → 4-(Pyridin-3-yl)-1,2-oxazol-5-amine

HRID 1604398Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1604398
CN(C)[CH:3]([C:6]1[CH:7]=[N:8][CH:9]=[CH:10][CH:11]=1)[C:4]#[N:5].Cl.[NH2:14]O.[C:16]([OH:19])(=O)C>>[NH2:14][C:16]1[O:19][N:5]=[CH:4][C:3]=1[C:6]1[CH:7]=[N:8][CH:9]=[CH:10][CH:11]=1

Komponenten

4

Edukt 3

HCID 176Acetic AcidHCID 443297Hydroxyamine hydrochlorideHCID 19603622HCID 19603622, Verbindung

Produkt 1

HCID 167406694-(Pyridin-3-yl)-1,2-oxazol-5-amine

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

To a solution of α-(dimethylamino)-α-(3-pyridyl)acetonitrile (5.19 g, 30 mmol) in acetic acid (40 ml) was added hydroxylamine hydrochloride (2.8 g, 40 mmol). The reaction mixture was stirred at 100° C. for 1 hour, cooled to room temperature and concentrated in vacuo. Water (50 ml) was added and the reaction mixture neutralized with solid potassium carbonate. The precipitated compound was filtered washed with water and dried giving the title compound in 4.2 g yield.

Aufarbeitung

  1. temperaturecooled to room temperature
  2. concentrationconcentrated in vacuo
  3. additionWater (50 ml) was added
  4. filtrationThe precipitated compound was filtered
  5. washwashed with water
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-44726756555341708a135445766640bd
Quelldatensatz
uspto-grants-1999_11
Patentnummer
US05994373

Notizen zur Reaktion

Wird geladen…