Water → 2-(4-Benzylmorpholin-2-yl)ethan-1-ol

HRID 1608216Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1608216
C([O:3][C:4]([CH2:6][CH:7]1[O:12][CH2:11][CH2:10][N:9]([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:8]1)=O)C.[H-].[Al+3].[Li+].[H-].[H-].[H-].C(OCC)(=O)C.O>C(OCC)C>[OH:3][CH2:4][CH2:6][CH:7]1[O:12][CH2:11][CH2:10][N:9]([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:8]1

Komponenten

6

Edukt 4

HCID 962WaterHCID 8857Ethyl AcetateHCID 12582571Ethyl (4-benzylmorpholin-2-yl)acetateHCID 21226445Aluminium lithium hydride2×

Produkt 1

HCID 146525912-(4-Benzylmorpholin-2-yl)ethan-1-olAusbeute 99,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel2×

Reaktionsbedingungen

Temperatur
25 °C

Versuchsvorschrift

A solution of 2-ethoxycarbonylmethyl-4-benzylmorpholine (41 g) in diethyl ether (100 ml) is added dropwise to a stirred suspension of lithium aluminum hydride (59.2 g) in diethyl ether (150 ml). The reaction mixture is stirred at 25° C. for 1 hour. The excess of lithium aluminum hydride is decomposed by the successive addition of ethyl acetate and water. The insoluble materials are filtered off, and the filtrate is evaporated to give the title compound (34.4 g) as an oil. The starting material, 2-ethoxycarbonylmethyl-4-benzylmorpholine, is prepared according to the method of F. Loftus [Syn. Commun., 10, 59-73 (1980)].

Aufarbeitung

  1. filtrationThe insoluble materials are filtered off
  2. customthe filtrate is evaporated

Quellen und Nachweise

ORD-Eintrag
ord-38c5b70e8f36445eab66d2f41d246acf
Quelldatensatz
uspto-grants-1989_09
Patentnummer
US04870074

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