Ethanol → 6-[2-(2-chloro-6-morpholin-4-yl-pyridin-3-yl)-benzoxazol-6-yl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one

HRID 1619979Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1619979
[Cl:1][C:2]1[C:7]([C:8]2[O:9][C:10]3[CH:16]=[C:15]([C:17]4[CH:18]([CH3:24])[CH2:19][C:20](=[O:23])[NH:21][N:22]=4)[CH:14]=[CH:13][C:11]=3[N:12]=2)=[CH:6][CH:5]=[C:4](Cl)[N:3]=1.[NH:26]1[CH2:31][CH2:30][O:29][CH2:28][CH2:27]1.C(O)C>O>[Cl:1][C:2]1[C:7]([C:8]2[O:9][C:10]3[CH:16]=[C:15]([C:17]4[CH:18]([CH3:24])[CH2:19][C:20](=[O:23])[NH:21][N:22]=4)[CH:14]=[CH:13][C:11]=3[N:12]=2)=[CH:6][CH:5]=[C:4]([N:26]2[CH2:31][CH2:30][O:29][CH2:28][CH2:27]2)[N:3]=1

Komponenten

5

Edukt 3

HCID 702EthanolHCID 8083MorpholineHCID 179935426-[2-(2,6-dichloro-pyridin-3-yl)-benzoxazol-6-yl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one

Produkt 1

HCID 866890706-[2-(2-chloro-6-morpholin-4-yl-pyridin-3-yl)-benzoxazol-6-yl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

1.1 g (2.9 mmol) 6-[2-(2,6-dichloro-pyridin-3-yl)-benzoxazol-6-yl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one, 1 ml morpholine and 50 ml of ethanol are refluxed together for 3 h, then the solv. is eliminated by rotary evaporation i.V., the residue is stirred with water and filtered off. The crude product is recrystallised from aqueous isopropanol.

Aufarbeitung

  1. filtrationfiltered off
  2. customThe crude product is recrystallised from aqueous isopropanol

Quellen und Nachweise

ORD-Eintrag
ord-fae0d78418c94f6e919393034d5d009a
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08772323B2

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