Methanol → 3-Bromo-2-methoxy-5-nitropyridine

HRID 1620102

Reaktionsgleichung

Reaktionsgleichung von HRID 1620102
[CH3:1][O-:2].[Na+].CO.[Br:6][C:7]1[C:8](Cl)=[N:9][CH:10]=[C:11]([N+:13]([O-:15])=[O:14])[CH:12]=1>O>[Br:6][C:7]1[C:8]([O:2][CH3:1])=[N:9][CH:10]=[C:11]([N+:13]([O-:15])=[O:14])[CH:12]=1

Komponenten

5

Edukt 3

HCID 887MethanolHCID 2308893-Bromo-2-chloro-5-nitropyridineHCID 10942334Sodium Methoxide

Produkt 1

HCID 215844513-Bromo-2-methoxy-5-nitropyridine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

Sodium methoxide (28% methanol solution) (2 ml) was added to a methanol (2 ml) solution containing 3-bromo-2-chloro-5-nitropyridine (100 mg), followed by stirring at room temperature for 1 hour. Water was added to the reaction solution, followed by extraction with ethyl acetate. The resultant was washed with saturated saline and dried over anhydrous sodium sulfate, the solvent was distilled away under reduced pressure, and a yellow solid of 3-bromo-2-methoxy-5-nitropyridine (96 mg) was thus obtained.

Aufarbeitung

  1. extractionfollowed by extraction with ethyl acetate
  2. washThe resultant was washed with saturated saline
  3. dry with materialdried over anhydrous sodium sulfate
  4. distillationthe solvent was distilled away under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-06f9c9a52fc6457d8c66c3707e9dcc82
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08772320B2

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