Hydrochloric Acid → [(2,3-Difluorobenzoyl)amino]acetic acid

HRID 1621179

Reaktionsgleichung

Reaktionsgleichung von HRID 1621179
[F:1][C:2]1[C:15]([F:16])=[CH:14][CH:13]=[CH:12][C:3]=1[C:4]([NH:6][CH2:7][C:8]([O:10]C)=[O:9])=[O:5].[OH-].[Li+].Cl>CO.O>[F:1][C:2]1[C:15]([F:16])=[CH:14][CH:13]=[CH:12][C:3]=1[C:4]([NH:6][CH2:7][C:8]([OH:10])=[O:9])=[O:5]

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 59816250Methyl [(2,3-difluorobenzoyl)amino]acetate

Produkt 1

HCID 59816243[(2,3-Difluorobenzoyl)amino]acetic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel2×

Versuchsvorschrift

To a solution of methyl [(2,3-difluorobenzoyl)amino]acetate (0.250 g, 1.1 mmol) in methanol (7 mL) were added lithium hydroxide (0.053 g, 2.2 mmol) and water (3 mL). The reaction mixture was allowed to stir overnight. The mixture was diluted with water (20 mL) and acidified with 1N HCl (5 mL). The product was partitioned into DCM/methanol (4:1). The organic layer was dried over sodium sulfate and the solvent removed to give [(2,3-difluorobenzoyl)amino]acetic acid which was used in the next step without purification.

Aufarbeitung

  1. customThe product was partitioned into DCM/methanol (4:1)
  2. dry with materialThe organic layer was dried over sodium sulfate
  3. customthe solvent removed

Quellen und Nachweise

ORD-Eintrag
ord-5e5e4963e62247e5bafe92166b9bd455
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08772536B2

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