StartseiteMCPWorkbenchSkills
StartseiteWorkbenchBenachrichtigungenMein Bereich
llms.txt · MCP-AnleitungDatenschutz · Nutzungsbedingungen · Supportv1.8.0
  1. Startseite
  2. /Reaktion

Methanol → 9-[4-(5-Cyano-pyridin-2-yloxymethyl)-3,3-dimethyl-2-oxo-pyrrolidin-1-yl]-bicyclo[3.3.1]nonane-3-carboxylic acid

HRID 16223
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 16223
[Li+].[OH-].C[O:4][C:5]([CH:7]1[CH2:14][CH:13]2[CH:15]([N:16]3[CH2:20][CH:19]([CH2:21][O:22][C:23]4[CH:28]=[CH:27][C:26]([C:29]#[N:30])=[CH:25][N:24]=4)[C:18]([CH3:32])([CH3:31])[C:17]3=[O:33])[CH:9]([CH2:10][CH2:11][CH2:12]2)[CH2:8]1)=[O:6].CO.O>O1CCCC1>[C:29]([C:26]1[CH:27]=[CH:28][C:23]([O:22][CH2:21][CH:19]2[CH2:20][N:16]([CH:15]3[CH:9]4[CH2:10][CH2:11][CH2:12][CH:13]3[CH2:14][CH:7]([C:5]([OH:6])=[O:4])[CH2:8]4)[C:17](=[O:33])[C:18]2([CH3:32])[CH3:31])=[N:24][CH:25]=1)#[N:30]
KomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

6

Edukt 4

HCID 887MethanolHCID 962WaterHCID 3939Lithium HydroxideHCID 666569249-[4-(5-Cyano-pyridin-2-yloxymethyl)-3,3-dimethyl-2-oxo-pyrrolidin-1-yl]-bicyclo[3.3.1]nonane-3-carboxylic acid methyl ester

Produkt 1

HCID 666569469-[4-(5-Cyano-pyridin-2-yloxymethyl)-3,3-dimethyl-2-oxo-pyrrolidin-1-yl]-bicyclo[3.3.1]nonane-3-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

LiOH (0.2 g, 4.84 mmol) was added in one portion to a stirred solution of the product of Example 7E (0.532 g, 1.21 mmol) in a mixture of tetrahydrofuran (6 mL), methanol (3 mL), and water (3 mL). The resulting solution was stirred overnight, followed by partitioning with diethyl ether and water. The organic layer was washed with water and the combined water layers were acidified with NaHSO4 solution and extracted with ethyl acetate. The combined ethyl acetate phases were dried (MgSO4), filtered, and evaporated. The acid product was used without further purification.

Aufarbeitung

  1. customby partitioning with diethyl ether and water
  2. washThe organic layer was washed with water
  3. extractionextracted with ethyl acetate
  4. dry with materialThe combined ethyl acetate phases were dried (MgSO4)
  5. filtrationfiltered
  6. customevaporated
  7. customThe acid product was used without further purification

Quellen und Nachweise

ORD-Eintrag
ord-011950e485cc4316bbf8c993b17121b2
Quelldatensatz
uspto-grants-2010_06
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US07737137B2

Notizen zur Reaktion

Wird geladen…

Auf dieser SeiteKomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion