Formic Acid → tert-Butyl 4-(piperazin-1-yl)piperidine-1-carboxylate

HRID 1631972Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1631972
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[CH2:19][CH2:18][N:17](C(OCC3C=CC=CC=3)=O)[CH2:16][CH2:15]2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].C(O)=O>CO.[Pd]>[N:14]1([CH:11]2[CH2:12][CH2:13][N:8]([C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:7])[CH2:9][CH2:10]2)[CH2:15][CH2:16][NH:17][CH2:18][CH2:19]1

Komponenten

5

Edukt 2

HCID 284Formic AcidHCID 18971584Benzyl 4-(1-(tert-butoxycarbonyl)piperidin-4-yl)piperazine-1-carboxylate

Produkt 1

HCID 17750358tert-Butyl 4-(piperazin-1-yl)piperidine-1-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A suspension of 3.01 g (7.46 mmol) of benzyl 4-(1-tert-butoxycarbonylpiperidin-4-yl)piperazine-1-carboxylate and 300 mg of Pd—C (5%) in 100 ml of methanol was mixed with 4 ml of formic acid and stirred under a hydrogen atmosphere (1 bar) at room temperature overnight. The reaction mixture was filtered through Celite, the residue on the filter was washed with methanol, and the solvent was then removed in vacuo. The residue was used without further purification in the next reaction step.

Aufarbeitung

  1. filtrationThe reaction mixture was filtered through Celite
  2. washthe residue on the filter was washed with methanol
  3. customthe solvent was then removed in vacuo
  4. customThe residue was used without further purification in the next reaction step

Quellen und Nachweise

ORD-Eintrag
ord-8ba3f999a16d423eaadad235ef330b09
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08791148B2

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