2-Methoxy-6-nitrophenylacetic acid → 4-Methoxy-2-indolinone
Reaktionsgleichung
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([N+:9]([O-])=O)[C:4]=1[CH2:12][C:13]([OH:15])=O>[Pd].C(O)(=O)C>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]2[C:4]=1[CH2:12][C:13](=[O:15])[NH:9]2Komponenten
4
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
A mixture of 2-methoxy-6-nitrophenylacetic acid (31 g, 150 mmol), and 3.0 g of 10% palladium on carbon in 200 mL of glacial acetic acid was stirred under an atmosphere of H2 gas until uptake ceased. The catalyst was filtered and the solvent evaporated in vacuo. The crude product was crystallized from methanol to give 9.0 g of the title compound.
Aufarbeitung
- filtrationThe catalyst was filtered
- customthe solvent evaporated in vacuo
- customThe crude product was crystallized from methanol
Quellen und Nachweise
- ORD-Eintrag
- ord-70dd1cf5d8894f15bdad729350d42a10
- Quelldatensatz
- uspto-grants-2003_01
- Patentnummer
- US06506901B2
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