4-Methylmorpholine → N,N-di-n-Butyl-2-benzyloxyacetamide

HRID 1635076

Reaktionsgleichung

Reaktionsgleichung von HRID 1635076
CN1CCOCC1.ClC(OCC(C)C)=O.[CH2:16]([O:23][CH2:24][C:25]([OH:27])=O)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.[CH2:28]([NH:32][CH2:33][CH2:34][CH2:35][CH3:36])[CH2:29][CH2:30][CH3:31]>C1COCC1.O>[CH2:28]([N:32]([CH2:33][CH2:34][CH2:35][CH3:36])[C:25](=[O:27])[CH2:24][O:23][CH2:16][C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1)[CH2:29][CH2:30][CH3:31]

Komponenten

7

Edukt 4

HCID 79724-Methylmorpholine2×HCID 8148DibutylamineHCID 62365Isobutyl chloroformateHCID 290301(Benzyloxy)acetic acid

Produkt 1

HCID 18675619N,N-di-n-Butyl-2-benzyloxyacetamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

3 g of N-methylmorpholine and 4 g of isobutyl chloroformate were successively added dropwise to 5 g of 2-benzyloxyacetic acid in 50 ml of THF at −10° C. The mixture was stirred for 10 minutes and then 5 ml of di-n-butylamine and a further 3 g of N-methylmorpholine were added. After one hour, the mixture was added to 500 ml of water and extracted several times with ether. The collected organic phases were dried over magnesium sulfate and, after removal of the solvent by distillation, 7 g of an oil were isolated and were immediately employed further.

Aufarbeitung

  1. waitAfter one hour
  2. extractionextracted several times with ether
  3. dry with materialThe collected organic phases were dried over magnesium sulfate
  4. customafter removal of the solvent
  5. distillationby distillation

Quellen und Nachweise

ORD-Eintrag
ord-72439baae5ef4e1f8fdc8da1bc0db42f
Quelldatensatz
uspto-grants-2003_01
Patentnummer
US06509341B1

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