Potassium Hydroxide → 2-Fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)aniline

HRID 16407

Reaktionsgleichung

Reaktionsgleichung von HRID 16407
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[NH:8][CH:9]=[CH:10][C:3]=12.[F:11][C:12]1[CH:18]=[C:17]([OH:19])[CH:16]=[CH:15][C:13]=1[NH2:14].[OH-].[K+]>O>[F:11][C:12]1[CH:18]=[C:17]([O:19][C:2]2[CH:7]=[CH:6][N:5]=[C:4]3[NH:8][CH:9]=[CH:10][C:3]=23)[CH:16]=[CH:15][C:13]=1[NH2:14]

Komponenten

5

Edukt 3

HCID 14797Potassium HydroxideHCID 27359194-Amino-3-fluorophenolHCID 113894934-Chloro-1H-pyrrolo[2,3-b]pyridine

Produkt 1

HCID 179793512-Fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)aniline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

100 mg (660 μmol) of 4-chloro-1H-pyrrolo[2,3-b]pyridine (from example XVIII), 166 mg (1.31 mmol) of 2-fluoro-4-hydroxyaniline and 73.5 mg (1.31 mmol) of powdered potassium hydroxide are heated at 260° C. for 8 hours. For work-up, the mixture is cooled to room temperature, diluted with water and extracted three times with ethyl acetate. The organic phase is dried over magnesium sulfate and concentrated using a rotary evaporator. The residue is purified by preparative HPLC.

Aufarbeitung

  1. extractionextracted three times with ethyl acetate
  2. dry with materialThe organic phase is dried over magnesium sulfate
  3. concentrationconcentrated
  4. customa rotary evaporator
  5. customThe residue is purified by preparative HPLC

Quellen und Nachweise

ORD-Eintrag
ord-b6ddfe09432349159627580791e74162
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07737153B2

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