Aluminum → Benzamide, N-(4-amino-5-chloro-2-hydroxyphenyl)-

HRID 1651748

Reaktionsgleichung

Reaktionsgleichung von HRID 1651748
[Al].[C:2]([NH:10][C:11]1[CH:16]=[C:15]([Cl:17])[C:14]([N+:18]([O-])=O)=[CH:13][C:12]=1[OH:21])(=[O:9])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>[Co].[Cr].[Ni]>[NH2:18][C:14]1[C:15]([Cl:17])=[CH:16][C:11]([NH:10][C:2](=[O:9])[C:3]2[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=2)=[C:12]([OH:21])[CH:13]=1

Komponenten

6

Edukt 2

HCID 5359268AluminumHCID 5483228Benzamide, N-(5-chloro-2-hydroxy-4-nitrophenyl)-

Produkt 1

HCID 78779Benzamide, N-(4-amino-5-chloro-2-hydroxyphenyl)-

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 935NickelKatalysatorHCID 23976ChromiumKatalysatorHCID 104730CobaltKatalysator2×

Versuchsvorschrift

Using the procedure described above and 5.0 g of a chromium-containing Raney cobalt catalyst containing about 20-30 weight percent aluminum, 1.5 to 2.5 weight percent nickel and the remainder cobalt, 2-benzamido 4-chloro 5-nitrophenol is hydrogenated for a total of 4 hours to obtain the corresponding amine, 5-amino 2-benzamido 4-chlorophenol. Analysis of a sample of the reaction mixture taken and analyzed in accordance with the procedure used in the preceding example, show that the purity of the product is 98.4 percent and the presence of 0.1 percent of dechlorinated by product. The azo, azoxy and hydroxylamine intermediate products are soluble in the final filtrate and thus are easily removed from the product. No starting material is detected.

Aufarbeitung

  1. customis hydrogenated for a total of 4 hours

Quellen und Nachweise

ORD-Eintrag
ord-c7ba2b9b250d4e90b4c69e31f0088994
Quelldatensatz
uspto-grants-1990_05
Patentnummer
US04929737

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