Water → 2-Bromo-1-(2,4-difluorophenyl)propan-1-one

HRID 1654180

Reaktionsgleichung

Reaktionsgleichung von HRID 1654180
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:12])[CH2:10][CH3:11].[Br:13]Br.O>C(Cl)Cl>[Br:13][CH:10]([CH3:11])[C:9]([C:3]1[CH:4]=[CH:5][C:6]([F:8])=[CH:7][C:2]=1[F:1])=[O:12]

Komponenten

5

Edukt 3

HCID 962WaterHCID 24408BromineHCID 1235862',4'-Difluoropropiophenone

Produkt 1

HCID 110758302-Bromo-1-(2,4-difluorophenyl)propan-1-oneAusbeute 98,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

In methylene chloride (300 ml) was dissolved 2',4'-difluoropropiophenone (55 g), to which was added bromine (50 g) dropwise, while stirring, during 30 minutes. The mixture was stirred for 30 minutes at room temperature. To the reaction mixture was added water (200 ml), and the methylene chloride layer was washed three times, followed by drying over anhydrous magnesium sulfate. The solvent was distilled off to leave 2-bromo-2',4'-difluoropropiophenone (77 g) as a pale yellow oily product.

Aufarbeitung

  1. stirringThe mixture was stirred for 30 minutes at room temperature
  2. washthe methylene chloride layer was washed three times
  3. dry with materialby drying over anhydrous magnesium sulfate
  4. distillationThe solvent was distilled off

Quellen und Nachweise

ORD-Eintrag
ord-7b5b9527b2b84a238e79ed329f9e217c
Quelldatensatz
uspto-grants-1995_04
Patentnummer
US05405861

Verknüpfte Notizen

Wird geladen…