Toluene → HCID 20076938, Verbindung

HRID 1654928Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1654928
[NH2:1][C:2]1[C:7]([O:8][CH2:9][C:10]2[C:15]([F:16])=[CH:14][CH:13]=[CH:12][C:11]=2[Cl:17])=[CH:6][C:5]([Cl:18])=[CH:4][N:3]=1.[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([N:26]=[C:27]=[S:28])=[CH:22][CH:21]=1.C1(C)C=CC=CC=1>CCOCC>[Cl:17][C:11]1[CH:12]=[CH:13][CH:14]=[C:15]([F:16])[C:10]=1[CH2:9][O:8][C:7]1[C:2]([NH:1][C:27]([NH:26][C:23]2[CH:24]=[CH:25][C:20]([Cl:19])=[CH:21][CH:22]=2)=[S:28])=[N:3][CH:4]=[C:5]([Cl:18])[CH:6]=1

Komponenten

5

Edukt 3

HCID 1140TolueneHCID 164804-Chlorophenyl isothiocyanateHCID 200770602-Amino-3-(2-chloro-6-fluorobenzyloxy)-5-chloropyridine

Produkt 1

HCID 20076938HCID 20076938, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

A mixture of 2-amino-3-(2-chloro-6-fluorobenzyloxy)-5-chloropyridine (0.82 g, 0.0028 mol), 4-chlorophenyl isothiocyanate (0.56 g, 0.0033 mol) and toluene (10 ml) was heated under reflux for 16 hours, then cooled and diluted with ether to induce crystallisation of the product, which was triturated with ethanol. Yield 0.68 g (54%), m.p. 158°-160 ° C.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureunder reflux for 16 hours
  3. temperaturecooled
  4. customcrystallisation of the product, which
  5. customwas triturated with ethanol

Quellen und Nachweise

ORD-Eintrag
ord-1f23fc8c37ec40be860f58665ec56d7b
Quelldatensatz
uspto-grants-1995_04
Patentnummer
US05409943

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