Acetic Anhydride → 2-Formylamino-4-(4-formylaminophenylthiomethyl)thiazole

HRID 1656972Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1656972
C(O[C:5](=[O:7])C)(=O)C.[CH:8]([NH:10][C:11]1[S:12][CH:13]=[C:14]([CH2:16][S:17][C:18]2[CH:23]=[CH:22][C:21]([NH2:24])=[CH:20][CH:19]=2)[N:15]=1)=[O:9]>C(O)=O>[CH:8]([NH:10][C:11]1[S:12][CH:13]=[C:14]([CH2:16][S:17][C:18]2[CH:23]=[CH:22][C:21]([NH:24][CH:5]=[O:7])=[CH:20][CH:19]=2)[N:15]=1)=[O:9]

Komponenten

4

Edukt 2

HCID 7918Acetic AnhydrideHCID 157291712-Formylamino-4-(4-aminophenylthiomethyl)thiazole

Produkt 1

HCID 157291722-Formylamino-4-(4-formylaminophenylthiomethyl)thiazoleAusbeute 96,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 284Formic AcidLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

A mixture of acetic anhydride (1.84 g) and formic acid (0.9 g) was heated at 50° C. for 0.5 hours with stirring. The solution was cooled at room temperature and to the solution was added the 2-formylamino-4-(4-aminophenylthiomethyl)thiazole (1.6 g). The mixture was stirred at room temperature for 6.5 hours and then the mixture was poured into ice-water. The precipitates were collected by filtration, washed with water and dried in vacuo to give 2-formylamino-4-(4-formylaminophenylthiomethyl)thiazole (1.7 g, yield: 96.7%). mp: 195°-197° C. (dec.)

Aufarbeitung

  1. temperatureThe solution was cooled at room temperature and to the solution
  2. stirringThe mixture was stirred at room temperature for 6.5 hours
  3. filtrationThe precipitates were collected by filtration
  4. washwashed with water
  5. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-e8bdc1367c2840b8a9a43c3d10efaff9
Quelldatensatz
uspto-grants-1993_10
Patentnummer
US05256675

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