Acetic Anhydride → 2-Acetoxy-2-(2-fluoro-4-biphenylyl)propionic acid

HRID 1659648Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1659648
[F:1][C:2]1[CH:7]=[C:6]([C:8]([OH:13])([CH3:12])[C:9]([OH:11])=[O:10])[CH:5]=[CH:4][C:3]=1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.[C:20](OC(=O)C)(=[O:22])[CH3:21]>O>[C:20]([O:13][C:8]([C:6]1[CH:5]=[CH:4][C:3]([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)=[C:2]([F:1])[CH:7]=1)([CH3:12])[C:9]([OH:11])=[O:10])(=[O:22])[CH3:21]

Komponenten

4

Edukt 2

HCID 7918Acetic AnhydrideHCID 233109062-(2-Fluorobiphenyl-4-yl)-2-hydroxypropanoic acid

Produkt 1

HCID 205597762-Acetoxy-2-(2-fluoro-4-biphenylyl)propionic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

(+)-2-(2-Fluoro-4-biphenylyl)-2-hydroxypropionic acid (1 g.) from Example 42 was added to acetic anhydride (10 g.) and the mixture stirred overnight at room temperature. The mixture was added to water (40 ml.) and allowed to stand for two hours. The product was collected and recrystallised from a mixture of ether and light petroleum (b.p. 62°-68° C.) to give (-)-2-acetoxy-2-(2-fluoro-4-biphenylyl)propionic acid, m.p. 125°-127° C. and [α]D20 -33.0°.

Aufarbeitung

  1. waitto stand for two hours
  2. customThe product was collected
  3. customrecrystallised from a mixture of ether and light petroleum (b.p. 62°-68° C.)

Quellen und Nachweise

ORD-Eintrag
ord-9d56491a46f347d1a57afa58104026dc
Quelldatensatz
uspto-grants-1981_12
Patentnummer
US04304931

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