Acetic Acid → HCID 67435756, Verbindung

HRID 1663386Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1663386
[Br:1][C:2]1[CH:3]=[C:4]([CH:12]2[C:21]3[C:20](=[O:22])[CH2:19][CH:18]([CH2:23][CH2:24][CH3:25])[CH2:17][C:16]=3[NH:15][C:14]([CH3:26])=[C:13]2[C:27]#[N:28])[CH:5]=[C:6]([N+:9]([O-])=O)[C:7]=1[OH:8].C(O)(=O)C>C1COCC1.[Zn]>[NH2:9][C:6]1[CH:5]=[C:4]([CH:12]2[C:21]3[C:20](=[O:22])[CH2:19][CH:18]([CH2:23][CH2:24][CH3:25])[CH2:17][C:16]=3[NH:15][C:14]([CH3:26])=[C:13]2[C:27]#[N:28])[CH:3]=[C:2]([Br:1])[C:7]=1[OH:8]

Komponenten

5

Edukt 2

HCID 176Acetic AcidHCID 67435380HCID 67435380, Verbindung

Produkt 1

HCID 67435756HCID 67435756, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23994ZincKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of 4-(3-bromo-4-hydroxy-5-nitro-phenyl)-2-methyl-5-oxo-7-propyl-1,4,5,6,7,8-hexahydro-quinoline-3-carbonitrile (15.8 g) and acetic acid (30 ml) in THF (300 ml), zinc dust (46 g) was added in portions, under vigorous stirring. After 2 h, the mixture was filtered and concentrated until a precipitate formed. This precipitate was collected by filtration and washed with ethanol.

Aufarbeitung

  1. filtrationthe mixture was filtered
  2. concentrationconcentrated until a precipitate
  3. customformed
  4. filtrationThis precipitate was collected by filtration
  5. washwashed with ethanol

Quellen und Nachweise

ORD-Eintrag
ord-0186cc4d90b04bcea0815fc10400198b
Quelldatensatz
uspto-grants-2011_10
Patentnummer
US08034945B2

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