Water → Tert-butyl (6-iodoimidazo[1,2-b]pyridazin-2-yl)carbamate

HRID 1663617

Reaktionsgleichung

Reaktionsgleichung von HRID 1663617
[NH2:1][C:2]1[N:3]=[N:4][C:5]([I:8])=[CH:6][CH:7]=1.Cl[CH2:10][C:11]([NH:13][C:14](=[O:20])[O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=O.P([O-])([O-])(O)=O.[Na+].[Na+].O>CN(C)C(=O)C>[I:8][C:5]1[CH:6]=[CH:7][C:2]2[N:3]([CH:10]=[C:11]([NH:13][C:14](=[O:20])[O:15][C:16]([CH3:19])([CH3:18])[CH3:17])[N:1]=2)[N:4]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 24203Sodium Phosphate, DibasicHCID 108678346-Iodopyridazin-3-amineHCID 14221822HCID 14221822, Verbindung

Produkt 1

HCID 46941915Tert-butyl (6-iodoimidazo[1,2-b]pyridazin-2-yl)carbamateAusbeute 63 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 31374DimethylacetamideLösungsmittel

Reaktionsbedingungen

Temperatur
120 °C

Versuchsvorschrift

To a solution of 3-amino-6-iodopyridazine (10.0 g, 45.2 mmol) in N,N-dimethylacetamide (100 mL) were added tert-butyl (chloroacetyl)carbamate (14.0 g, 72.4 mmol) and disodium hydrogenphosphate (16.1 g, 113 mmol), and the mixture was stirred at 120° C. for 3 hr. After cooling the mixture to room temperature, water (400 mL) was added to the mixture, and the precipitated crystals were filtrated, and washed with acetonitrile and petroleum ether to give the title compound (10.2 g, 63%) as a green powder.

Aufarbeitung

  1. temperatureAfter cooling the mixture to room temperature
  2. filtrationthe precipitated crystals were filtrated
  3. washwashed with acetonitrile and petroleum ether

Quellen und Nachweise

ORD-Eintrag
ord-a0e9ff83a97a417aa675e8332b54e6f3
Quelldatensatz
uspto-grants-2011_10
Patentnummer
US08034812B2

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