Methanethiol → HCID 58970391, Verbindung

HRID 1678045Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1678045
Cl[CH:2]([C:4]1[N:9]=[C:8]([O:10][CH3:11])[CH:7]=[C:6]([O:12][CH3:13])[N:5]=1)[CH3:3].[Na].[CH3:15][SH:16].O>CN(C=O)C>[CH3:15][S:16][CH:2]([C:4]1[N:9]=[C:8]([O:10][CH3:11])[CH:7]=[C:6]([O:12][CH3:13])[N:5]=1)[CH3:3]

Komponenten

6

Edukt 4

HCID 878MethanethiolHCID 962WaterHCID 5360545SodiumHCID 58970392HCID 58970392, Verbindung

Produkt 1

HCID 58970391HCID 58970391, VerbindungAusbeute 90,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

2-(1-Chloroethyl)-4,6-dimethoxypyrimidine 15.5 g (76.5 mmol) was dissolved in DMF 200 ml and sodium salt of methylmercaptan 5.4 g (76.5 mmol) was added thereto at room temperature. The solution was stirred at 50° C. for 1 hour. The reaction solution was poured into water and extracted with ethyl acetate. The solvent was distilled off and the residue was purified with column chromatography (hexane/ethyl acetate=5/1) to obtain 2-(1-methylthioethyl)-4,6-dimethoxypyrimidine 14.8 g (90%).

Aufarbeitung

  1. customat room temperature
  2. extractionextracted with ethyl acetate
  3. distillationThe solvent was distilled off
  4. customthe residue was purified with column chromatography (hexane/ethyl acetate=5/1)

Quellen und Nachweise

ORD-Eintrag
ord-829315c078c2458eac85f88329381094
Quelldatensatz
uspto-grants-2011_08
Patentnummer
US08008484B2

Notizen zur Reaktion

Wird geladen…