Methanol → 1-Cyclopropylpiperazine

HRID 16819

Reaktionsgleichung

Reaktionsgleichung von HRID 16819
Cl.Cl.[CH:3]1([N:6]2[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]2)[CH2:5][CH2:4]1.CO>O>[CH:3]1([N:6]2[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]2)[CH2:5][CH2:4]1

Komponenten

4

Edukt 2

HCID 887MethanolHCID 212208121-Cyclopropylpiperazine dihydrochloride

Produkt 1

HCID 47420041-CyclopropylpiperazineAusbeute 84,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

1-Cyclopropylpiperazine dihydrochloride (1.493 g, 7.5 mmol) was dissolved in water (5.00 mL) and methanol (5.00 mL) and converted to its freebase by ion exchange chromatography, using an SCX column. The desired product was eluted from the column using 3.5M ammonia in methanol and pure fractions were evaporated to dryness to afford 1-cyclopropylpiperazine (0.796 g, 84%) as an oil.

Aufarbeitung

  1. washThe desired product was eluted from the column
  2. customwere evaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-52133c47f1534988bfc9e04dd961a467
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07737149B2

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