Guanidine Hydrochloride → 2,4-Diamino-6-(2,3-dihydro-3-hydroxy-2,2-dimethylbenzofuran-7-yl)pteridine

HRID 1683690Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1683690
C[O-].[Na+].Cl.[NH2:5][C:6]([NH2:8])=[NH:7].N[C:10]1[C:15]([C:16]#[N:17])=[N:14][C:13]([C:18]2[C:26]3[O:25][C:24]([CH3:28])([CH3:27])[CH:23]([OH:29])[C:22]=3[CH:21]=[CH:20][CH:19]=2)=[CH:12][N:11]=1>CO>[NH2:7][C:6]1[N:8]=[C:16]([NH2:17])[C:15]2[C:10](=[N:11][CH:12]=[C:13]([C:18]3[C:26]4[O:25][C:24]([CH3:27])([CH3:28])[CH:23]([OH:29])[C:22]=4[CH:21]=[CH:20][CH:19]=3)[N:14]=2)[N:5]=1

Komponenten

5

Edukt 3

HCID 5742Guanidine HydrochlorideHCID 10942334Sodium MethoxideHCID 190407832-Amino-3-cyano-5-(2,3-dihydro-3-hydroxy-2,2-dimethylbenzofuran-7-yl)pyrazine

Produkt 1

HCID 190407812,4-Diamino-6-(2,3-dihydro-3-hydroxy-2,2-dimethylbenzofuran-7-yl)pteridine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 2.8 grams (0.052 mole) of sodium methoxide in 100 mL of methanol is stirred, and 1.9 grams (0.019 mole) of guanidine hydrochloride is added. Upon completion of addition, the reaction mixture is stirred for about 5 minutes and then is filtered to remove sodium chloride. The filtrate is then added to 4.5 grams (0.016 mole) of 2-amino-3-cyano-5-(2,3-dihydro-3-hydroxy-2,2-dimethylbenzofuran-7-yl)pyrazine. The stirring reaction mixture is then heated to reflux where it is stirred for about 18 hours. After this time the reaction mixture is cooled and filtered. The filter cake is washed with water and dried, yielding 2,4-diamino-6-(2,3-dihydro-3-hydroxy-2,2-dimethylbenzofuran-7-yl)pteridine.

Aufarbeitung

  1. additionUpon completion of addition
  2. filtrationis filtered
  3. customto remove sodium chloride
  4. customThe stirring reaction mixture
  5. temperatureis then heated
  6. temperatureto reflux where it
  7. stirringis stirred for about 18 hours
  8. temperatureAfter this time the reaction mixture is cooled
  9. filtrationfiltered
  10. washThe filter cake is washed with water
  11. customdried

Quellen und Nachweise

ORD-Eintrag
ord-41ee4e09632a4893ba503fb304e6d9fb
Quelldatensatz
uspto-grants-1997_06
Patentnummer
US05639753

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