2-Bromo-1-(4-hydroxyphenyl)ethanone → Bromide ion

HRID 1683719

Reaktionsgleichung

Reaktionsgleichung von HRID 1683719
NC1N(CCN2CCOCC2)C2C=CC=CC=2N=1.[OH:19][C:20]1[CH:29]=[CH:28][C:23]([C:24](=[O:27])[CH2:25][Br:26])=[CH:22][CH:21]=1>C(Cl)(Cl)Cl.C(OCC)(=O)C>[OH:19][C:20]1[CH:29]=[CH:28][C:23]([C:24](=[O:27])[CH3:25])=[CH:22][CH:21]=1.[Br-:26]

Komponenten

6

Edukt 2

HCID 49642-Bromo-1-(4-hydroxyphenyl)ethanoneHCID 5680111-(2-Morpholin-4-ylethyl)-2-aminobenzimidazole

Produkt 2

HCID 259Bromide ionHCID 74694'-Hydroxyacetophenone

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6212ChloroformLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A mixture of 2-amino-1-(2-morpholinoethyl)benzimidazole (10 mmol, 2.46 g) and 4-hydroxyphenacyl bromide (10 mmol, 2.15 g) (obtained by bromination of parahydroxyacetophenone with cuptic bromide in a mixture of chloroform and ethyl acetate) is heated at reflux for 1 hour in 10 ml of dimethylformamide. After cooling, the mixture is poured into 50 ml of water and rendered alkaline with ammonium hydroxide. The resulting oil is removed and treated with water. The crystallised residue is filtered, dried, and recrystallised from ethanol.

Quellen und Nachweise

ORD-Eintrag
ord-fbf72edcbdf84c8588c19e90bbd2b9b4
Quelldatensatz
uspto-grants-1997_06
Patentnummer
US05639756

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