Benzaldehyde → Benzaldehyde, 2,6-dichloro-, oxime

HRID 1689746

Reaktionsgleichung

Reaktionsgleichung von HRID 1689746
[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([Cl:10])[C:3]=1[CH:4]=O.Cl.[NH2:12][OH:13].[OH-].[Na+].C(=O)C1C=CC=CC=1>O.CO>[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([Cl:10])[C:3]=1[CH:4]=[N:12][OH:13]

Komponenten

7

Edukt 4

HCID 240BenzaldehydeHCID 67372,6-DichlorobenzaldehydeHCID 14798Sodium Hydroxide2×HCID 443297Hydroxyamine hydrochloride

Produkt 1

HCID 91328Benzaldehyde, 2,6-dichloro-, oxime

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel2×

Versuchsvorschrift

2,6-Dichloro-benzaldehyde (7.0 g, 40 mmol) and hydroxylamine hydrochloride (2.16 g, 44 mmol) are added to 10 mL of water and 30 mL of methanol. Sodium hydroxide (4.0 g, 100 mmol) is dissolved in 8 mL of water slowly. The sodium hydroxide solution is added to the benzaldehyde solution. The reaction is stirred overnight. The reaction mixture is partitioned between ethyl acetate and water. The organic layer is washed with brine and dried over solid sodium sulfate. The organic layer is filtered and the solvent is removed under reduced pressure to yield the title compound.

Aufarbeitung

  1. customThe reaction mixture is partitioned between ethyl acetate and water
  2. washThe organic layer is washed with brine
  3. dry with materialdried over solid sodium sulfate
  4. filtrationThe organic layer is filtered
  5. customthe solvent is removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-91b4da23681b4de2a3466fc951868c49
Quelldatensatz
uspto-grants-2012_04
Patentnummer
US08153624B2

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