Acetic Acid → N6-(1-Oxohexadecyl)-L-lysine

To the solution of L-lysine (1 mmol) in water (2 ml) and triethylamine (0.27 ml, 2 mmol) 1 mmol of succinimidyl palmitate (suspended in 2 ml of acetone) was added at room temperature under stirring. Stirring of the reaction mixture was continued for 4h. Triethylamine was removed under reduced pressure, the precipitate was collected by filtration, washed with water and ethanol, crystallized from glacial acetic acid giving an 86% yield of the title compound. Analysis data are given in Table 2.

1. stirringStirring of the reaction mixture
2. customTriethylamine was removed under reduced pressure
3. filtrationthe precipitate was collected by filtration
4. washwashed with water and ethanol

ORD-Eintrag

ord-e5237ac844f14b98bc5496c6a6836a6c

Quelldatensatz

uspto-grants-1978_11

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US04126628