Water → 2,4-Dimethoxypyrimidine-5-carbaldehyde

HRID 1707954

Reaktionsgleichung

CCCCCC.Br[C:8]1[C:9]([O:16][CH3:17])=[N:10][C:11]([O:14][CH3:15])=[N:12][CH:13]=1.[CH:18](OCC)=[O:19].O>CCOCC>[CH:18]([C:8]1[C:9]([O:16][CH3:17])=[N:10][C:11]([O:14][CH3:15])=[N:12][CH:13]=1)=[O:19]

Komponenten

Reaktionsbedingungen

Temperatur: -70 °C

Versuchsvorschrift

A solution of 1.6M n-Buli in hexane (48 ml, 73.6 mmol) was added over 5 min. to a stirred suspension of 5-bromo-2,4-dimethoxypyrimidine (16 g; 72.9 mmol) in dry Et2O (240 ml) at -70° C. under an atmosphere of dry N2. Dry ethyl formate (28 g: 377 mmol) was added and the orange solution stirred at -70° C. for 1 h then allowed to warm slowly to ambient temperature. Water (400 ml) was added and the aqueous layer separated and extracted with Et2O (3×200 ml). The ether layer was combined with the extracts and dried over MgSO4, filtered and evaporated. The residue was purified by column chromatography by preloading in SiO2 and eluting with EtOAc-hexane (3:7, v/v). Product fractions were combined and evaporated to give fine white needles, yield 6.89 g, (56%). Mass spectrum m/z 169 (M+H)+Analysis, found: C, 50:1;H,4.5;N,16.9%;C7H8N2O3 requires C,50.00; H,4.79; N, 16.66%.

Aufarbeitung

temperatureto warm slowly to ambient temperature
customthe aqueous layer separated
extractionextracted with Et2O (3×200 ml)
dry with materialdried over MgSO4
filtrationfiltered
customevaporated
customThe residue was purified by column chromatography
washeluting with EtOAc-hexane (3:7, v/v)
customevaporated
customto give fine white needles, yield 6.89 g, (56%)

Quellen und Nachweise

ORD-Eintrag: ord-d44ba53f2f18452188175c5c1e01b82f
Quelldatensatz: uspto-grants-1994_10
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US05356882

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