Ethanolamine → N-(2-Hydroxyethyl)heptanamide

HRID 1708392Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1708392
[CH2:1]([CH2:3][NH2:4])[OH:2].C(N(CC)CC)C.[C:12](Cl)(=[O:19])[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18].O>O1CCCC1>[OH:2][CH2:1][CH2:3][NH:4][C:12](=[O:19])[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]

Komponenten

6

Edukt 4

HCID 700EthanolamineHCID 962WaterHCID 8471TriethylamineHCID 17313Heptanoyl chloride

Produkt 1

HCID 14455153N-(2-Hydroxyethyl)heptanamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

A solution of ethanolamine (8.00 mL, 133 mmol) and triethylamine (20.0 mL, 143 mmol) in tetrahydrofuran (200 mL) was cooled to 0° C., and a solution of heptanoyl chloride (20.0 mL, 129 mmol) in tetrahydrofuran (50 mL) was added dropwise over 30 minutes. After stirring an additional 18 hours, the reaction mixture was poured into water (400 mL), and extracted with methylene chloride (2×300 mL). The extracts were combined, dried over anhydrous magnesium sulfate and evaporated to afford the solid product (N-(2-hydroxyethyl)-heptanamide), which was recrystallized to purity from ether-hexane (22.3 g, 129 mmol, 100%), melting point 91°-93° C. 1H NMR (CDCl3): 6.31 (1H, br s); 3.75-3.68 (2H, m); 3.55-3.39 (3H, m); 2.21 (2H, t, J=7.2 Hz); 1.69-1.58 (2H, m); 1.39-1.24 (6H, m); 0.88 (3H, t, J=6.6 Hz).

Aufarbeitung

  1. extractionextracted with methylene chloride (2×300 mL)
  2. dry with materialdried over anhydrous magnesium sulfate
  3. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-b55d9ba50765499eb7f87c5ed3cff4b7
Quelldatensatz
uspto-grants-1994_10
Patentnummer
US05358946

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