Sodium Iodide → 1-Chloro-2-(iodomethyl)benzene

A mixture of 2-chlorophenylmethylbromide (4 g, 19.47 mmol) and NaI (14 g, 97.33 mmol) in acetone (40 ml) was stirred under reflux for 1 hour. The reaction mixture was cooled, filtered and concentrated in vacuo. The residue was triturated with hexane and filtered. The solution was concentrated in vacuo, and the resulting oil purified by flash chromatography (silica, hexane) to afford the title compound (4.67 g, 63%) as an oil: 1H NMR (CDCl3) δ 7.34 (4H, m), 4.54 (2H, s).

1. temperatureunder reflux for 1 hour
2. temperatureThe reaction mixture was cooled
3. filtrationfiltered
4. concentrationconcentrated in vacuo
5. customThe residue was triturated with hexane
6. filtrationfiltered
7. concentrationThe solution was concentrated in vacuo
8. customthe resulting oil purified by flash chromatography (silica, hexane)

ORD-Eintrag

ord-42ed71f0a2e147309f522e21f0b590c6

Quelldatensatz

uspto-grants-2010_09

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07790713B2