2-Amino-4-methylpyridine → Ethyl 1-{5-[6-(4-methylpyridin-2-ylamino)pyridin-2-yl]thiazol-2-yl}piperidine-4-carboxylate

Reaktionsgleichung

C1(P(C2C=CC=CC=2)C2C=CC3C(=CC=CC=3)C=2C2C3C(=CC=CC=3)C=CC=2P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[NH2:47][C:48]1[CH:53]=[C:52]([CH3:54])[CH:51]=[CH:50][N:49]=1.[CH2:55]([O:57][C:58]([CH:60]1[CH2:65][CH2:64][N:63]([C:66]2[S:67][C:68]([C:71]3[CH:76]=[CH:75][CH:74]=[C:73](Br)[N:72]=3)=[CH:69][N:70]=2)[CH2:62][CH2:61]1)=[O:59])[CH3:56].C(=O)([O-])[O-].[Cs+].[Cs+]>C1(C)C=CC=CC=1.C([O-])(=O)C.[Pd+2].C([O-])(=O)C.O>[CH3:54][C:52]1[CH:51]=[CH:50][N:49]=[C:48]([NH:47][C:73]2[N:72]=[C:71]([C:68]3[S:67][C:66]([N:63]4[CH2:62][CH2:61][CH:60]([C:58]([O:57][CH2:55][CH3:56])=[O:59])[CH2:65][CH2:64]4)=[N:70][CH:69]=3)[CH:76]=[CH:75][CH:74]=2)[CH:53]=1