Hydrogen Bromide → 3-amino-2-phenyl-2,3-dihydro-1,5-benzothiazepin-4(5H)-one hydrobromide

HRID 1719116Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1719116
C(OC([NH:11][CH:12]1[C:18](=[O:19])[NH:17][C:16]2[CH:20]=[CH:21][CH:22]=[CH:23][C:15]=2[S:14][CH:13]1[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)=O)C1C=CC=CC=1.CCOCC.[BrH:35]>C(O)(=O)C>[BrH:35].[NH2:11][CH:12]1[C:18](=[O:19])[NH:17][C:16]2[CH:20]=[CH:21][CH:22]=[CH:23][C:15]=2[S:14][CH:13]1[C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

Komponenten

5

Edukt 3

HCID 260Hydrogen BromideHCID 3283Diethyl EtherHCID 134905083-benzyloxycarbonylamino-2-phenyl-2,3-dihydro-1,5-benzothiazepin-4(5H)-one

Produkt 1

HCID 199935893-amino-2-phenyl-2,3-dihydro-1,5-benzothiazepin-4(5H)-one hydrobromide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel2×

Versuchsvorschrift

5.4 g of the compound obtained in Example 2 was dissolved in a 25% solution of hydrogen bromide in acetic acid. After the lapse of 2 hours, 15 ml of acetic acid was added to the solution and the resulting mixture was stirred for an hour. After the addition of ether, the precipitated crystals were separated by filtration and washed with ether to obtain 4.0 g of the desired compound.

Aufarbeitung

  1. customthe precipitated crystals were separated by filtration
  2. washwashed with ether

Quellen und Nachweise

ORD-Eintrag
ord-7288c878400646f29737b69e45b98104
Quelldatensatz
uspto-grants-1985_09
Patentnummer
US04539150

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