5-Methoxy-N,N-dimethyl-1H-indole-3-methanamine → 5-methoxy-3-methyl-1H-indole

HRID 1719383

Reaktionsgleichung

Reaktionsgleichung von HRID 1719383
CN([CH2:4][C:5]1[C:9]2[CH:10]=[C:11]([O:14][CH3:15])[CH:12]=[CH:13][C:8]=2[NH:7][CH:6]=1)C>C(O)C.[Pd]>[CH3:15][O:14][C:11]1[CH:10]=[C:9]2[C:8](=[CH:13][CH:12]=1)[NH:7][CH:6]=[C:5]2[CH3:4]

Komponenten

4

Edukt 1

HCID 279655-Methoxy-N,N-dimethyl-1H-indole-3-methanamine

Produkt 1

HCID 111374445-methoxy-3-methyl-1H-indole

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 5-methoxygramine (3.96 g) in absolute ethanol (80 ml) with 10% Palladium on carbon (0.40 g) is hydrogenated at atmospheric pressure for 10 hours. The catalyst is removed by vacuum filtration through Hy-Flo and the filtrate is concentrated in vacuo to give an oil which crystallizes on standing to give 5-methoxy-3-methylindole.

Aufarbeitung

  1. customThe catalyst is removed by vacuum filtration through Hy-Flo
  2. concentrationthe filtrate is concentrated in vacuo
  3. customto give an oil which
  4. customcrystallizes

Quellen und Nachweise

ORD-Eintrag
ord-6cdae33fd9de43bfb99ee90950b755ec
Quelldatensatz
uspto-grants-1985_09
Patentnummer
US04539410

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