Nitric Acid → 4-(1-Methylpropyl)-2-nitrophenol

HRID 1723007

Reaktionsgleichung

Reaktionsgleichung von HRID 1723007
O.[CH:2]([C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=1)([CH2:4][CH3:5])[CH3:3].[N+:13]([O-])([OH:15])=[O:14]>CCOCC>[CH:2]([C:6]1[CH:7]=[CH:8][C:9]([OH:12])=[C:10]([N+:13]([O-:15])=[O:14])[CH:11]=1)([CH2:4][CH3:5])[CH3:3]

Komponenten

5

Edukt 3

HCID 944Nitric AcidHCID 962WaterHCID 74534-sec-Butylphenol

Produkt 1

HCID 190854-(1-Methylpropyl)-2-nitrophenol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

To a stirred mixture of 50 ml of water, 50 ml of ether and 10.0 g of 4-sec-butylphenol was added dropwise, 7.5 ml of 61% nitric acid was added dropwise while cooling with ice. After, the temperature of the mixture was raised to room temperature and the reaction was continued for 4 days. The reaction mixture was extracted with 300 ml of ethyl acetate, washed with a brine and dried with anhydrous sodium sulfate. The drying agent was filtered off and the solvent was distilled away. The residue was purified by subjecting to silica-gel column-chromatography [eluent:chloroform] to give 14.71 g of 4-sec-butyl-2-nitrophenol.

Aufarbeitung

  1. additionwas added dropwise
  2. temperaturewhile cooling with ice
  3. extractionThe reaction mixture was extracted with 300 ml of ethyl acetate
  4. washwashed with a brine
  5. dry with materialdried with anhydrous sodium sulfate
  6. filtrationThe drying agent was filtered off
  7. distillationthe solvent was distilled away
  8. customThe residue was purified

Quellen und Nachweise

ORD-Eintrag
ord-04bff3161a584e8d916e77a66dbd2775
Quelldatensatz
uspto-grants-1989_08
Patentnummer
US04859661

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