N-Hydroxysuccinimide → HCID 59811150, Verbindung

6-Amino-3′-trifluoromethyl-[2,2′]bipyridinyl-5-carboxylic acid hydrochloride (11.33 g, 35.44 mmol), N-hydroxy-succinimide (8.15 g, 70.9 mmol), and EDCl (10.19 g, 53.16 mmol) are dissolved in a solution of dry THF (100 mL) and Hunig's base (16.12 g, 125 mmol). The reaction mixture is stirred overnight at room temperature. Ethyl acetate (200 mL) is added and the organic phase extracted with water (3×100 mL) and brine (100 mL). The organic extract is dried over Na2SO4 and the solvent removed under reduced pressure to yield the title compound as a brown foam.

1. extractionthe organic phase extracted with water (3×100 mL) and brine (100 mL)
2. extractionThe organic extract
3. dry with materialis dried over Na2SO4
4. customthe solvent removed under reduced pressure

ORD-Eintrag

ord-29011105759a4605ba3554e3833f0e77

Quelldatensatz

uspto-grants-2009_02

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07488740B2