Acetonitrile → 2-Phenyl-6-oxo-5-phenylacetylamino-1,6-dihydropyrimidine

HRID 1726363Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1726363
C(#N)C.[Na].[CH2:5]([C:12]1[O:13][C:14](=O)[C:15](=[CH:17][OH:18])[N:16]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.Cl.[C:21]([NH2:29])(=[NH:28])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>O>[C:22]1([C:21]2[NH:29][C:17](=[O:18])[C:15]([NH:16][C:12](=[O:13])[CH2:5][C:6]3[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=3)=[CH:14][N:28]=2)[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

Komponenten

5

Edukt 3

HCID 6342AcetonitrileHCID 80289Benzamidine, hydrochlorideHCID 178519094HCID 178519094, Verbindung

Produkt 1

HCID 116524352-Phenyl-6-oxo-5-phenylacetylamino-1,6-dihydropyrimidineAusbeute 75,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

Acetonitrile (6 ml) was added to 2-benzyl-4-hydroxymethylene-5-oxazolone sodium salt (0.50 g, 2.22 mmol) and benzamidine hydrochloride (0.35 g, 2.22 mmol), and the mixture was stirred overnight at 80° C. Water (3 ml) was added, and the mixture was stirred. The precipitate was collected by filtration, and the obtained crystals were washed with water and vacuum dried to give 2-phenyl-6-oxo-5-phenylacetylamino-1,6-dihydropyrimidine (0.51 g, 1.67 mmol).

Aufarbeitung

  1. stirringthe mixture was stirred
  2. filtrationThe precipitate was collected by filtration
  3. washthe obtained crystals were washed with water and vacuum
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-ae925aba04ee43d7acd4cca4028f6894
Quelldatensatz
uspto-grants-2009_02
Patentnummer
US07491822B2

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