Bromine → HCID 11663376, Verbindung

HRID 1727346

Reaktionsgleichung

Reaktionsgleichung von HRID 1727346
[C:1]([O:5][C:6]([NH:8][C:9]1[CH:14]=[C:13]([CH2:15][C:16]([C:18]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=2)=[O:17])[CH:12]=[CH:11][N:10]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[Br:26]Br>C(O)(=O)C>[BrH:26].[Br:26][CH:15]([C:13]1[CH:12]=[CH:11][N:10]=[C:9]([NH:8][C:6]([O:5][C:1]([CH3:3])([CH3:4])[CH3:2])=[O:7])[CH:14]=1)[C:16]([C:18]1[CH:19]=[CH:20][C:21]([O:24][CH3:25])=[CH:22][CH:23]=1)=[O:17]

Komponenten

4

Edukt 2

HCID 24408BromineHCID 116170921-(4-Methoxyphenyl)-2-(2-tert-butoxycarbonylamino-4-pyridyl)ethanone

Produkt 1

HCID 11663376HCID 11663376, VerbindungAusbeute 159,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

To a solution of 2-(2-tert-butoxycarbonylamino-4-pyridyl)-1-(4-methoxyphenyl)ethanone (0.36 g, 1.1 mmol) in acetic acid (5 mL) was added bromine (0.058 mL, 1.1 mmol), and the mixture was stirred for 1 hour at room temperature. The reaction mixture was concentrated, and the residue was washed with isopropyl ether to obtain a title compound (0.44 g, yield 82%).

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated
  2. washthe residue was washed with isopropyl ether

Quellen und Nachweise

ORD-Eintrag
ord-4679bfd453d644878906341df7417124
Quelldatensatz
uspto-grants-2009_02
Patentnummer
US07495018B2

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