Acetic Acid → 4-Bromo-3-fluoro-6-iodo-2-methoxy-5-methylphenylamine

HRID 17301

Reaktionsgleichung

Reaktionsgleichung von HRID 17301
[I:1]N1C(=O)CCC1=O.C(O)(=O)C.[Br:13][C:14]1[C:20]([CH3:21])=[CH:19][C:17]([NH2:18])=[C:16]([O:22][CH3:23])[C:15]=1[F:24]>[Cl-].[Na+].O>[Br:13][C:14]1[C:20]([CH3:21])=[C:19]([I:1])[C:17]([NH2:18])=[C:16]([O:22][CH3:23])[C:15]=1[F:24]

Komponenten

5

Edukt 3

HCID 176Acetic AcidHCID 120273N-IodosuccinimideHCID 860974514-Bromo-3-fluoro-2-methoxy-5-methylaniline

Produkt 1

HCID 860974524-Bromo-3-fluoro-6-iodo-2-methoxy-5-methylphenylamine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 57417360Sodium chloride; waterLösungsmittel

Versuchsvorschrift

N-iodosuccinimide (1.91 g, 8.5 mmol) was added to an acetic acid (40 ml) solution of 4-bromo-3-fluoro-2-methoxy-5-methylaniline (I-43) (1.90 g, 8.1 mmol), followed by stirring at room temperature for 67 hours. Saturated brine was added to the reaction liquid, followed by extraction twice with ethyl acetate, the organic layer was washed three times with saturated brine, dried over anhydrous magnesium sulfate.

Aufarbeitung

  1. extractionfollowed by extraction twice with ethyl acetate
  2. washthe organic layer was washed three times with saturated brine
  3. dry with materialdried over anhydrous magnesium sulfate

Quellen und Nachweise

ORD-Eintrag
ord-3933087f8a4a4ed49b2bc3f566af531a
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07737166B2

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