Trityl chloride → HCID 70604455, Verbindung

HRID 1730313Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1730313
[C:1](Cl)([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:21][C:22]1([CH3:34])[S:26][C@@H:25]2[C@H:27]([NH2:30])[C:28](=[O:29])[N:24]2[C@H:23]1[C:31](O)=O.C([N:37](CC)CC)C>C(Cl)(Cl)Cl>[C:2]1([C:1]([NH:30][CH:27]2[C:28](=[O:29])[N:24]3[CH:23]([C:31]#[N:37])[C:22]([CH3:34])([CH3:21])[S:26][C@H:25]23)([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 6456Trityl chlorideHCID 8471TriethylamineHCID 110826-Aminopenicillanic acid

Produkt 1

HCID 70604455HCID 70604455, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

Tritylchloride (61.2 g., 0.22 mole) is added to a mixture of 6-aminopenicillanic acid (43.3 g., 0.20 mole) and triethylamine (5.56 ml.)in chloroform (300 ml.) at about 5° C. The somewhat exothermic reaction is stirred and allowed to rise gradually to room temperature. It is stirred at room temperature for three days. Evaporation of the reactionmixture affords the title product which is used without purification.

Aufarbeitung

  1. customat about 5° C
  2. customThe somewhat exothermic reaction
  3. customto rise gradually to room temperature
  4. stirringIt is stirred at room temperature for three days
  5. customEvaporation of the reactionmixture

Quellen und Nachweise

ORD-Eintrag
ord-60ee0b7ffdb844f98d0b8cddf91f57ec
Quelldatensatz
uspto-grants-1976_11
Patentnummer
US03992394

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