Acetic Acid → HCID 20300371, Verbindung

HRID 1733148Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1733148
[NH2:1][C:2]1[O:3][CH:4]=[C:5]([C:9]([CH3:12])([CH3:11])[CH3:10])[C:6]=1[C:7]#[N:8].[C:13](O)(=[O:15])[CH3:14].C(OC(=O)C)(=O)C>>[C:13]([NH:1][C:2]1[O:3][CH:4]=[C:5]([C:9]([CH3:12])([CH3:11])[CH3:10])[C:6]=1[C:7]#[N:8])(=[O:15])[CH3:14]

Komponenten

4

Edukt 3

HCID 176Acetic AcidHCID 7918Acetic AnhydrideHCID 13770581HCID 13770581, Verbindung

Produkt 1

HCID 20300371HCID 20300371, VerbindungAusbeute 83,4 %

Versuchsvorschrift

16.4 g (0.1 mole) of 2-amino-3-cyano-4-tert.-butylfuran were heated to 100° C. with 24 ml (0.4 mole) of acetic acid and 10.4 ml (0.11 mole) of acetic anhydride for one hour. Thereafter, the reaction mixture was evaporated under reduced pressure and the residue was recrystallized from a mixture of toluene/cyclohexane (1:2). 17.2 g of 2-acetylamino-3-cyano-4-tert.-butyl-furan of melting point 135° C. were obtained in this manner.

Aufarbeitung

  1. customThereafter, the reaction mixture was evaporated under reduced pressure
  2. customthe residue was recrystallized from a mixture of toluene/cyclohexane (1:2)

Quellen und Nachweise

ORD-Eintrag
ord-906e8f6c272a4d838725e739580d17b5
Quelldatensatz
uspto-grants-1980_12
Patentnummer
US04240820

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