Dicyclohexylcarbodiimide → N-[N-trifluoroacetyl-4-(hexadecylamino)benzoyloxy]succinimide

HRID 1733535

Reaktionsgleichung

Reaktionsgleichung von HRID 1733535
[F:1][C:2]([F:32])([F:31])[C:3]([N:5]([C:22]1[CH:30]=[CH:29][C:25]([C:26]([OH:28])=[O:27])=[CH:24][CH:23]=1)[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])=[O:4].O1CCOCC1.O[N:40]1[C:44](=[O:45])[CH2:43][CH2:42][C:41]1=[O:46].C1(N=C=NC2CCCCC2)CCCCC1>O.CCCCCC>[F:1][C:2]([F:31])([F:32])[C:3]([N:5]([C:22]1[CH:30]=[CH:29][C:25]([C:26]([O:28][N:40]2[C:44](=[O:45])[CH2:43][CH2:42][C:41]2=[O:46])=[O:27])=[CH:24][CH:23]=1)[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])=[O:4]

Komponenten

7

Edukt 4

HCID 10868DicyclohexylcarbodiimideHCID 312751,4-DioxaneHCID 80170N-HydroxysuccinimideHCID 20437350N-trifluoroacetyl-4-(hexadecylamino)benzoic acid

Produkt 1

HCID 20437360N-[N-trifluoroacetyl-4-(hexadecylamino)benzoyloxy]succinimide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8058HexaneLösungsmittel

Versuchsvorschrift

To a stirred ice-cold solution of 18.3 g. of p-(2,2,2-trifluoro-N-hexadecylacetamido)benzoic acid in 80 ml. of dioxane is added successively 4.84 g. of N-hydroxysuccinimide and 9.16 g. of dicyclohexylcarbodiimide. After 18 hours at 0°-5° C. the mixture is stirred vigorously for one hour with hexane and water and filtered. The hexane layer is washed with water, dried over magnesium sulfate, and concentrated to give an oil.

Aufarbeitung

  1. filtrationfiltered
  2. washThe hexane layer is washed with water
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated
  5. customto give an oil

Quellen und Nachweise

ORD-Eintrag
ord-0f1885cfa1f74558b0d15ce0b3bfe68c
Quelldatensatz
uspto-grants-1980_12
Patentnummer
US04242273

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