Water → N-(2-Benzoylphenyl)-2-bromoacetamide

HRID 1734323

Reaktionsgleichung

Reaktionsgleichung von HRID 1734323
[Br:1][CH2:2][C:3](Br)=[O:4].[NH2:6][C:7]1[CH:20]=[CH:19][CH:18]=[CH:17][C:8]=1[C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:10].O>ClCCl>[Br:1][CH2:2][C:3]([NH:6][C:7]1[CH:20]=[CH:19][CH:18]=[CH:17][C:8]=1[C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:10])=[O:4]

Komponenten

5

Edukt 3

HCID 962WaterHCID 61147Bromoacetyl bromideHCID 760802-Aminobenzophenone

Produkt 1

HCID 84439N-(2-Benzoylphenyl)-2-bromoacetamideAusbeute 97,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Reaktionsbedingungen

Temperatur
-5 °C

Versuchsvorschrift

A solution of bromoacetyl bromide (100 mL, 1.15 mol, Aldrich) dissolved in dichloromethane (300 mL) was added over 30 min to a solution of 2-aminobenzophenone (197 g, 1.0 mol, Fluka) dissolved in dichloromethane (1.3 L) and water (100) mL) cooled to -10° C. under vigorous mechanical stirring. The resulting mixture was stirred for an additional 1 h at -5° C. and then was allowed to warm to ambient temperature. The layers were separated, and the organic extract was washed with dilute sodium bicarbonate, then was dried over sodium sulfate. Evaporation afforded 309.8 g (95%) of 2-bromoacetamidobenzophenone as off-white crystals.

Aufarbeitung

  1. temperatureto warm to ambient temperature
  2. customThe layers were separated
  3. extractionthe organic extract
  4. washwas washed with dilute sodium bicarbonate
  5. dry with materialwas dried over sodium sulfate
  6. customEvaporation

Quellen und Nachweise

ORD-Eintrag
ord-6e118f0a3ce64569a0e2cefa1d0f7ad9
Quelldatensatz
uspto-grants-1996_07
Patentnummer
US05532359

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