2,3-Dihydroxybutanedioic Acid → HCID 178418492, Verbindung

HRID 1737936

Reaktionsgleichung

Reaktionsgleichung von HRID 1737936
[C:1]([OH:10])(=[O:9])[CH:2]([CH:4]([C:6]([OH:8])=[O:7])[OH:5])[OH:3].[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([CH2:18][C:19]([O:21][C@H:22]2[CH2:27][CH2:26][C@H:25]([C:28]3[CH:33]=[CH:32][C:31]([CH2:34][N:35]([CH3:37])[CH3:36])=[CH:30][CH:29]=3)[CH2:24][CH2:23]2)=[O:20])=[CH:14][CH:13]=1.C(OCC)C>C(O)C>[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([CH2:18][C:19]([O:21][C@H:22]2[CH2:23][CH2:24][C@H:25]([C:28]3[CH:29]=[CH:30][C:31]([CH2:34][N:35]([CH3:36])[CH3:37])=[CH:32][CH:33]=3)[CH2:26][CH2:27]2)=[O:20])=[CH:14][CH:13]=1.[C:6]([CH:4]([CH:2]([C:1]([O-:10])=[O:9])[OH:3])[OH:5])([O-:8])=[O:7]

Komponenten

5

Edukt 3

HCID 8752,3-Dihydroxybutanedioic AcidHCID 3283Diethyl EtherHCID 178418347HCID 178418347, Verbindung

Produkt 1

HCID 178418492HCID 178418492, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

First 0.15 g (0.001 mol) of anhydrous tartaric acid and then 0.39 g (0.001 mol) of trans-O-(4-chlorophenylacetyl)-4-(4-dimethylaminomethylphenyl)-cyclohexanol are dissolved in 7 ml of absolute ethanol. Diethyl ether is then added to the clear solution until it becomes slightly cloudy and it is then left to stand for 8 hours at +4° C. The crystalline product precipitated is suction filtered, washed with diethyl ether and dried. Melting point: 169-171° C. Yield: 0.46 g (86% of theory) C27H34ClNO8 (536.02) Calculated: C 60.50 H 6.39 N 2.61 Cl 6.61 Found: 60.37 6.38 2.65 6.73

Aufarbeitung

  1. waitit is then left
  2. customThe crystalline product precipitated
  3. filtrationfiltered
  4. washwashed with diethyl ether
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-55ea716c4e3c44d0a4770bffc28542b2
Quelldatensatz
uspto-grants-1999_10
Patentnummer
US05962507

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