Ethanol → N-(2-Hydroxy-4-methylphenyl)acetamide

Temperatur

80 °C

To a mixture of 40 ml of ethanol with 60 ml of water, there was added 20.0 g (16.3 mmol) of 6-amino-m-cresol, followed by heating to 80° C. To the obtained solution, there was added dropwise 17.4 g (17.1 mmol) of acetic anhydride over 10 minutes and the mixture was stirred at 80° C. for 15 minutes. After the completion of the reaction, the mixture was cooled to 10° C. The crystals thus precipitated were filtered, washed with water and dried. Thus 23.9 g (15.0 mmol) of N-(2-hydroxy-4-methylphenyl)acetamide was obtained as pale brown crystals. The yield was 89%. A 20.0 g portion of this product was recrystallized from acetonitrile to thereby give 17.9 g of N-(2-hydroxy-4-methylphenyl)acetamide as colorless crystals. The recovering yield was 90%.

1. customAfter the completion of the reaction
2. temperaturethe mixture was cooled to 10° C
3. customThe crystals thus precipitated
4. filtrationwere filtered
5. washwashed with water
6. customdried

ORD-Eintrag

ord-32048139e4284adc86817ac2caeebff7

Quelldatensatz

uspto-grants-1994_08

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05334225