1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 89586102, Verbindung

HRID 1747835Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1747835
[CH3:1][O:2][C:3]1[C:4](=[O:22])[C:5]([C:19](O)=[O:20])=[N:6][N:7]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[CH:10]=2)[CH:8]=1.[CH3:23][C:24]([C:27]([O:29][CH3:30])=[O:28])([CH3:26])[NH2:25].C1C=CC2N(O)N=NC=2C=1.CCN=C=NCCCN(C)C.C(N(CC)C(C)C)(C)C>C1COCC1.O>[CH3:1][O:2][C:3]1[C:4](=[O:22])[C:5]([C:19]([NH:25][C:24]([CH3:26])([C:27]([O:29][CH3:30])=[O:28])[CH3:23])=[O:20])=[N:6][N:7]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[CH:10]=2)[CH:8]=1

Komponenten

8

Edukt 5

HCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 757711-HydroxybenzotriazoleHCID 81531DiisopropylethylamineHCID 4186341Methyl 2-amino-2-methylpropanoateHCID 594362475-Methoxy-4-oxo-1-[3-(trifluoromethyl)phenyl]-1,4-dihydropyridazine-3-carboxylic acid

Produkt 1

HCID 89586102HCID 89586102, VerbindungAusbeute 85,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A mixture of 5-methoxy-4-oxo-1-[3-(trifluoromethyl)phenyl]-1,4-dihydropyridazine-3-carboxylic acid (300 mg), methyl 2-methylalaninate (134 mg), HOBt (219 mg), WSC (275 mg) and N,N-diisopropylethylamine (0.834 mL) in THF (3.18 mL) was stirred at room temperature for 17 hr, and water was added. The precipitate was collected by filtration, and washed with water and hexane to give the title compound (336 mg).

Aufarbeitung

  1. filtrationThe precipitate was collected by filtration
  2. washwashed with water and hexane

Quellen und Nachweise

ORD-Eintrag
ord-6f46fe89a255440dbbea40f68a3b527e
Quelldatensatz
uspto-grants-2015_10
Patentnummer
US09150588B2

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