Acetic Acid → 6-nitro-1H-indole-3-carbaldehyde

HRID 1749748

Reaktionsgleichung

Reaktionsgleichung von HRID 1749748
[N+:1]([C:4]1[CH:12]=[C:11]2[C:7]([CH:8]=[CH:9][NH:10]2)=[CH:6][CH:5]=1)([O-:3])=[O:2].[C:13](O)(=[O:15])C.C1N2CN3CN(C2)CN1C3>O>[N+:1]([C:4]1[CH:12]=[C:11]2[C:7]([C:8]([CH:13]=[O:15])=[CH:9][NH:10]2)=[CH:6][CH:5]=1)([O-:3])=[O:2]

Komponenten

5

Edukt 3

HCID 176Acetic AcidHCID 4101HexamethylenetetramineHCID 785026-Nitro-1H-indole

Produkt 1

HCID 52100766-nitro-1H-indole-3-carbaldehydeAusbeute 77 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Reaktionsbedingungen

Temperatur
120 °C

Versuchsvorschrift

6-Nitroindole (1.0 g, 6.2 mmol) was successively added with acetic acid (2.5 mL), water (5.0 mL), and hexamethylenetetramine (1.2 g, 8.4 mmol), and then the mixture was stirred overnight at 120° C. in a sealed tube. The reaction mixture was added with water, and the precipitated solid was collected by filtration, and then dried to obtain 6-nitro-1H-indole-3-carboxaldehyde (0.91 g, 77%).

Aufarbeitung

  1. filtrationthe precipitated solid was collected by filtration
  2. customdried

Quellen und Nachweise

ORD-Eintrag
ord-716b45a55ff14e2fafb06dc475b3bfe6
Quelldatensatz
uspto-grants-2015_10
Patentnummer
US09156827B2

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