Acetic Acid → 6-Methyl-1h-pyrrolo[2,3-b]pyridine-3-carbaldehyde

HRID 1749811Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1749811
[CH3:1][C:2]1[N:7]=[C:6]2[NH:8][CH:9]=[CH:10][C:5]2=[CH:4][CH:3]=1.[C:11](O)(=[O:13])C.C1N2CN3CN(C2)CN1C3>O>[CH3:1][C:2]1[N:7]=[C:6]2[NH:8][CH:9]=[C:10]([CH:11]=[O:13])[C:5]2=[CH:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 176Acetic AcidHCID 4101HexamethylenetetramineHCID 114577166-Methyl-1H-pyrrolo[2,3-b]pyridine

Produkt 1

HCID 247295536-Methyl-1h-pyrrolo[2,3-b]pyridine-3-carbaldehydeAusbeute 67 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Reaktionsbedingungen

Temperatur
120 °C

Versuchsvorschrift

6-Methyl-1H-pyrrolo[2,3-b]pyridine (0.066 g, 0.50 mmol) was successively added with acetic acid (0.2 mL), water (0.4 mL), and hexamethylenetetramine (0.098 g, 0.70 mmol), and then the mixture was stirred overnight at 120° C. in a sealed tube. The reaction mixture was added with water, and then the precipitated solid was collected by filtration to obtain 6-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde (0.054 g, 67%).

Aufarbeitung

  1. filtrationthe precipitated solid was collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-c33c572ec4ca43839d20afa4e0002597
Quelldatensatz
uspto-grants-2015_10
Patentnummer
US09156827B2

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