Formic Acid → (R)-1-(3-Chlorophenyl)ethanol
Reaktionsgleichung
C([O-])=O.[K+].C(O)=O.[Cl:8][C:9]1[CH:10]=[C:11]([C:15](=[O:17])[CH3:16])[CH:12]=[CH:13][CH:14]=1>[Ru].CO>[Cl:8][C:9]1[CH:10]=[C:11]([C@H:15]([OH:17])[CH3:16])[CH:12]=[CH:13][CH:14]=1Komponenten
6
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Reaktionsbedingungen
- Temperatur
- 50 °C
Versuchsvorschrift
A ruthenium complex RuCl[(R,R)-Tsdpen] (mesitylene) (2.1 mg, 0.0033 mmol), potassium formate (1.0 g, 12 mmol), formic acid (138 mg, 3 mmol) and 3′-chloroacetophenone (1.55 g, 10 mmol, substrate/catalyst ratio=3000) were set in a 20 mL glass Schlenk-type reaction tube under an argon atmosphere. Methanol (6 mL) was added thereto and stirred at 50° C. for 24 hours to give (R)-1-(3′-chlorophenyl)ethanol at 100% yield and 96.5% ee optical purity.
Quellen und Nachweise
- ORD-Eintrag
- ord-c069fcffd9ad4384ad4742a821f2db62
- Quelldatensatz
- uspto-grants-2015_10
- Patentnummer
- US09162934B2
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