Bromine → 6-Amino-5-bromopyridine-3-carbonitrile

HRID 1752214

Reaktionsgleichung

Reaktionsgleichung von HRID 1752214
[Br:1]Br.[NH2:3][C:4]1[CH:11]=[CH:10][C:7]([C:8]#[N:9])=[CH:6][N:5]=1>CC(O)=O>[NH2:3][C:4]1[C:11]([Br:1])=[CH:10][C:7]([C:8]#[N:9])=[CH:6][N:5]=1

Komponenten

4

Edukt 2

HCID 24408BromineHCID 8182602-Amino-5-cyanopyridine

Produkt 1

HCID 14912506-Amino-5-bromopyridine-3-carbonitrileAusbeute 49,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

Br2 (0.52 mL, 0.01 mol) was added to a solution of 6-aminonicotinonitrile (1.1901 g, 0.01 mol) in AcOH (10 mL) at room temperature. The mixture was stirred at room temperature for 2 h. Then the mixture was concentrated and the residue was purified by flash column chromatography to give the title product (980.0 mg, 49%).

Aufarbeitung

  1. concentrationThen the mixture was concentrated
  2. customthe residue was purified by flash column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-3c3f73d384034bff9d09d4b9052641f3
Quelldatensatz
uspto-grants-2015_10
Patentnummer
US09162980B2

Verknüpfte Notizen

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