Isopropanol → 4-[4-(3-Chloro-1H-indazol-5-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

HRID 175357Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 175357
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11]([c:14]2[cH:15][c:16]3[c:17]([n:18][cH:19][n:20][c:21]3[Cl:22])[nH:23]2)=[CH:12][CH2:13]1.[C:74]([O:75][C:76]([O:77][C:78]([O:79][C:80]([CH3:81])([CH3:82])[CH3:83])=[O:84])=[O:85])([CH3:86])([CH3:87])[CH3:88].[CH:35]([OH:36])([CH3:37])[CH3:38].[CH:65]([N:66]([CH2:67][CH3:68])[CH:69]([CH3:70])[CH3:71])([CH3:72])[CH3:73].[Cl:39][c:40]1[c:41]2[c:42]([cH:43][cH:44][c:45]([NH:46][c:47]3[c:48]4[cH:49][c:50]([C:51]5=[CH:56][CH2:55][NH:54][CH2:53][CH2:52]5)[nH:57][c:58]4[n:59][cH:60][n:61]3)[cH:62]2)[nH:63][n:64]1.[NH2:24][c:25]1[cH:26][c:27]2[c:28]([Cl:34])[n:29][nH:30][c:31]2[cH:32][cH:33]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11]([c:14]2[cH:15][c:16]3[c:17]([n:18][cH:19][n:20][c:21]3[NH:24][c:25]3[cH:26][c:27]4[c:28]([Cl:34])[n:29][nH:30][c:31]4[cH:32][cH:33]3)[nH:23]2)=[CH:12][CH2:13]1

Komponenten

7

Edukt 6

HCID 3776IsopropanolHCID 81531DiisopropylethylamineHCID 90495Di-tert-butyl dicarbonateHCID 58709797tert-butyl 4-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-3,6-dihydropyridine-1(2H)-carboxylateHCID 178478422(3-chloro-1H-indazol-5-yl)-[6-(1,2,3,6-tetrahydropyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-amineHCID 178507360HCID 178507360, Verbindung

Produkt 1

HCID 1784517324-[4-(3-Chloro-1H-indazol-5-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

Quellen und Nachweise

ORD-Eintrag
ord-9d4f4efd119b48e987cb3fbaed8c04e3
Quelldatensatz
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

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