Butylamine → (E)-N-ethyl-6,6-dimethyl-N-[[3-[(4-thiophen-3-ylthiophen-2-yl)methoxy]phenyl]methyl]hept-2-en-4-yn-1-amine

To 10 ml of tetrahydrofuran were added 1.01 g (2.5 mmol) of (E)-N-(3-chloro-2-propenyl)-N-ethyl-3-[4-(3-thienyl)-2-thienylmethyoxy]benzylamine, 23.8 mg (0.125 mmol) of copper (I) iodide, 8.9 mg (0.05 mmol) of palladium chloride and 26.2 mg (0.1 mmol) of triphenylphosphine, and further, 0.50 ml (5.0 mmol) of n-butylamine and 0.37 ml (3.0 mmol) of tert-butylacetylene under ice cooling. The mixture was stirred for 17 hours at room temperature, and extracted with a mixture of 70 ml of ethyl acetate and 30 ml of water. The organic layer was separated, washed with a mixture of 40 ml of water and 4 ml of 2N hydrochloric acid, a mixture of 40 ml of water and 6 ml of saturated sodium bicarbonate aqueous solution and 20 ml of saturated sodium chloride aqueous solution and then dried over anhydrous magnesium sulfate. After ethyl acetate was evaporated under reduced pressure, the residue was treated with 3 ml of methanol, and stirred for 17 hours under ice cooling. The resulting crystals were collected by filtration, washed with 2 ml of methanol and dried under reduced pressure to obtain 0.81 g (yield: 72%) of the above identified compound as slightly yellowish brown crystalline powder.

1. extractionextracted with a mixture of 70 ml of ethyl acetate and 30 ml of water
2. customThe organic layer was separated
3. washwashed with a mixture of 40 ml of water and 4 ml of 2N hydrochloric acid
4. additiona mixture of 40 ml of water and 6 ml of saturated sodium bicarbonate aqueous solution and 20 ml of saturated sodium chloride aqueous solution
5. dry with materialdried over anhydrous magnesium sulfate
6. customAfter ethyl acetate was evaporated under reduced pressure
7. additionthe residue was treated with 3 ml of methanol
8. stirringstirred for 17 hours under ice cooling
9. filtrationThe resulting crystals were collected by filtration
10. washwashed with 2 ml of methanol
11. customdried under reduced pressure
12. customto obtain 0.81 g (yield: 72%) of the

ORD-Eintrag

ord-b0aed7a0d23b42f6b998153404e89b10

Quelldatensatz

uspto-grants-1995_08

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05440049