Hydrochloric Acid → HCID 19390688, Verbindung

HRID 1756591Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1756591
[C:1]([C:6]1[CH:7]=[C:8]2[C:20](=[CH:21][CH:22]=1)[N:19]1[C:10](=[N:11][C:12]3[C:17]([C:18]1=[O:23])=[CH:16][CH:15]=[CH:14][CH:13]=3)[C:9]2=[O:24])([O:3]CC)=[O:2].Cl>C[Si](I)(C)C.CCOCC.[OH-].[Na+]>[C:1]([C:6]1[CH:7]=[C:8]2[C:20](=[CH:21][CH:22]=1)[N:19]1[C:10](=[N:11][C:12]3[C:17]([C:18]1=[O:23])=[CH:16][CH:15]=[CH:14][CH:13]=3)[C:9]2=[O:24])([OH:3])=[O:2]

Komponenten

6

Edukt 2

HCID 313Hydrochloric AcidHCID 478657HCID 478657, Verbindung

Produkt 1

HCID 19390688HCID 19390688, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 3283Diethyl EtherLösungsmittelHCID 14798Sodium HydroxideLösungsmittelHCID 85247Trimethylsilyl iodideLösungsmittel

Versuchsvorschrift

A solution of 8-carboethoxyindolo[2,1-b]quinazoline-6,12-dione (2 mmol, from Example 42) in 3 mL of trimethylsilyl iodide (TMSI) is heated to 100° C. for 4 h. The reaction mixture is cooled to room temperature, diluted with ether, and 3 mL of 0.5N NaOH solution is added. The reaction mixture is acidified with 6N HCl and extracted with chloroform. The chloroform extracts are dried, filtered, and concentrated to give 8-carboxyindolo[2,1-b]quinazoline-6,12-dione.

Aufarbeitung

  1. additionis added
  2. extractionextracted with chloroform
  3. dry with materialThe chloroform extracts are dried
  4. filtrationfiltered
  5. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-ce1f83515d604c89b694691b2e6445e0
Quelldatensatz
uspto-grants-1995_08
Patentnummer
US05441955

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